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similar to pds5, which interacts with the chromosomal cohesion complex and modulates the cohesion of chromosomes and kinetochores in ways that are only now being explored (see Dorsett, Chromosoma 116, 1-13 (2007). Pds5 is related to nipped-B, for which Dicty also has a probable homolog (DDB_G0283099). The role of pds5 in Dicty cell cycle control is supported by its sixfold overexpression in a Dicty strain lacking the retinoblastoma-like gene rblA (Doquang et al, 2009 in preparation). Most genes whose products are involved in cell cycle progression are overexpressed in this strain.

Harry MacWilliams, April 2009

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