Pds5

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-similar to pds5, which interacts with the chromosomal cohesion complex and modulates the cohesion of chromosomes and kinetochores in ways that are only now being explored (see Dorsett, Chromosoma 116, 1-13 (2007). Pds5 is related to nipped-B, for which Dicty also has a probable homolog (DDB_G0283099). The role of pds5 in Dicty cell cycle control is supported by its sixfold overexpression in a Dicty strain lacking the retinoblastoma-like gene rblA (Doquang et al, 2009). Most genes whose products are involved in cell cycle progression are overexpressed in this strain.+similar to pds5, which interacts with the chromosomal cohesion complex and modulates the cohesion of chromosomes and kinetochores in ways that are only now being explored (see Dorsett, Chromosoma 116, 1-13 (2007). Pds5 is related to nipped-B, for which Dicty also has a probable homolog (DDB_G0283099). The role of pds5 in Dicty cell cycle control is supported by its sixfold overexpression in a Dicty strain lacking the retinoblastoma-like gene rblA (Doquang et al, 2009 in preparation). Most genes whose products are involved in cell cycle progression are overexpressed in this strain.
Harry MacWilliams, April 2009 Harry MacWilliams, April 2009

Current revision

similar to pds5, which interacts with the chromosomal cohesion complex and modulates the cohesion of chromosomes and kinetochores in ways that are only now being explored (see Dorsett, Chromosoma 116, 1-13 (2007). Pds5 is related to nipped-B, for which Dicty also has a probable homolog (DDB_G0283099). The role of pds5 in Dicty cell cycle control is supported by its sixfold overexpression in a Dicty strain lacking the retinoblastoma-like gene rblA (Doquang et al, 2009 in preparation). Most genes whose products are involved in cell cycle progression are overexpressed in this strain.

Harry MacWilliams, April 2009

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